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与新生儿听力查相关的向性细胞巨乳病毒检测是可行的,但诊断收益率低

Emilie Luppescu Pedersen¹, Kirsten Fenger Hvilsted^1,2, Janko Moritz³

¹Department of Paediatrics and Adolescent Medicine, Slagelse Hospital, Slagelse, Denmark.

Acta paediatrica (Oslo, Norway : 1992)

|October 21, 2025

概括

针对新生儿的先天性细胞巨乳病毒 (cCMV) 的听力查改善了测试率,但诊断收益率较低. 发现尿样在婴儿cCMV查中比唾液更可靠.

科学领域:

儿科听力学儿科听力学
传染病查传染病查
新生儿健康新生儿健康

背景情况:

先天性细胞巨化病毒 (cCMV) 是儿童非遗传性听力损失的主要原因.
早期检测和干预对于管理cCMV相关的听力损伤至关重要.

研究的目的:

评估针对新生儿的cCMV听力查的可实施性.
为了确定这种查策略是否能改善患病婴儿的治疗时间.

主要方法:

在丹麦西兰地区 (2018年6月 - 2024年5月) 对未能接受听力查的新生儿进行回顾性队列研究.
查实施前后的cCMV检测率,检测时的年龄和样本类型 (唾液与尿液) 的比较.

主要成果:

在查实施后,cCMV测试从6%增加到90%.
唾液样本显示高错误阳性率;尿液样本没有评估错误阳性.
没有任何患有cCMV相关听力损失的婴儿被诊断得足够早以开始治疗.

结论:

听力向的cCMV查是可以实施的,但在这种情况下的诊断收益率很低.
尿样似乎比唾液更适合针对新生儿进行cCMV查.

关键词:

遗传性感染遗传性感染细胞巨型病毒 (cytomegalovirus) 是一种病毒.听力损失听力损失是什么新生婴儿听力查新生婴儿听力查有针对性的查.

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Cytomegalovirus Disease

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...