大麻素系统作为酒精相关肝病的潜在新目标:一种倾向匹配的队列研究
Butros Fakhoury1, Vinay Jahagirdar2, Kaanthi Rama2
1Department of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
概括
大麻使用,特别是大麻使用障碍,可能会降低酒精相关肝病 (ALD) 和酒精使用障碍 (AUD) 患者相关并发症的风险. 这表明大麻素是ALD的潜在治疗点.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
背景情况:
- 与酒精相关的肝病 (ALD) 具有严重的健康负担,治疗选择有限.
- 临床前研究表明,大麻 (CBD) 可能减轻酒精引起的肝损伤.
- 关于在酒精使用障碍 (AUD) 患者中使用大麻治疗ALD的临床数据很少.
研究的目的:
- 调查大麻使用与在被诊断为AUD的患者中发展ALD的风险之间的关联.
- 为了在AUD人口中比较不同大麻使用模式中的ALD,肝衰竭和死亡率的风险.
主要方法:
- 一个回顾性队列研究利用TrinetX美国协作网络 (2010-2022).
- 建立了三个患者队列:大麻使用障碍 (CUD),没有滥用/依赖的大麻使用者 (CU) 和非大麻使用者 (非CU).
- 倾向性得分匹配和考克斯回归分析被用于评估包括ALD,肝衰竭和三年全因死亡率在内的结果.
主要成果:
- 在倾向匹配的队列中,与非CU患者相比,CUD与ALD (HR 0.60),肝衰竭 (HR 0.83) 和全因死亡率 (HR 0.86) 的风险降低有显著关联.
- 大麻使用者 (CU) 的ALD风险降低,但与非CU相比,除偿和死亡风险相似.
- 在CUD患者中观察到最显著的ALD和相关结局风险降低.
结论:
- 大麻使用,特别是CUD,与AUD患者的ALD和相关并发症风险降低有关.
- 这些发现突出了调节大麻素受体作为ALD治疗策略的潜力.
- 对与酒精相关的肝病的基于大麻素的疗法进行进一步的研究是有必要的.
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