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一个关于由161Tb和177Lu在多细胞原子模型中诱导的DNA损伤的Geant4-DNA研究

Ali Azizi Ganjgah¹, Payvand Taherparvar¹

¹Department of Physics, Faculty of Sciences, University of Guilan, Rasht, Iran.

International journal of radiation biology

|October 21, 2025

概括

该研究发现,161 (Tb) 在细胞模型中比177 (Lu) 诱导更多的DNA链断裂. 这表明¹⁶¹Tb对于向癌症治疗可能更有效,特别是对于集群瘤细胞.

科学领域:

医学物理医学物理
辐射生物学辐射生物学
放射性药物疗法是一种放射性药物疗法.

背景情况:

向放射性核酸治疗利用放射性同位素向癌细胞输送细胞毒剂量.
了解不同放射性核酸的DNA损伤诱导对于优化治疗疗效和最大限度地减少非目标效应至关重要.
161Tb和177Lu是新兴的治疗性放射性核酸,具有独特的发射特性.

研究的目的:

量化由161Tb和177Lu引起的直接和间接DNA链断裂 (单链断裂,双链断裂,混合DSB).
在多细胞模型中评估自身细胞和邻细胞效应.
为了比较不同目标源配置的161Tb和177Lu的DNA损伤潜力.

主要方法:

使用Geant4-DNA工具包进行蒙特卡洛模拟.
开发了一种具有13个球形细胞的多细胞原子模型,以六角密集的配置.
包括完整的β减光谱,奥格尔电子,转换电子和来自161Tb和177Lu的光子辐射.

主要成果:

在自我细胞效应中,Tb诱导的DNA链断裂大约比Lu更多13%.
¹⁶¹Tb在邻近细胞效应中比¹⁷⁷Lu诱导大约21%的DNA链断裂.
电子是DNA损伤的主要贡献者,而光子的影响最小.

结论:

与177相比,Tb显示了诱导DNA链断裂的更高潜力.
这些发现表明¹⁶¹Tb是向放射性核酸治疗的有希望的候选人,特别是针对单个和集群瘤细胞.
该研究为优化放射性核酸治疗中的剂量计和治疗计划提供了有价值的数据.

关键词:

161Tbb,这是一个巨大的数字.177Lu 177Lu 177Lu 177Lu 177Lu 177Lu 177Lu 177Lu 177Lu 177Lu 177 造成的DNA损伤是DNA损伤.吉安特的4-DNA是一种DNA.蒙特卡洛模拟的蒙特卡洛模拟

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