在共刺激阻塞下,口服抗原暴露会诱导Treg细胞建立免疫耐受性

Masaya Arai1, Ryoji Kawakami1,2, Yamami Nakamura1

  • 1Department of Experimental Immunology, Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.

概括

口服抗原养会产生调节性T (Treg) 细胞,但在原始宿主中很难诱导耐受性. 使用CTLA4-Ig阻断CD28共刺激促进稳定的CD101+Treg细胞生成以获得全身口服耐受性.

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