康杰克葡萄干对功能性便秘运动员的胃肠道症状和肠道微生物群的影响:双盲随机对照试验
Yuping Zhu1, Xuelian Chen1, Gang Song2
1Institute of Sport Science, College of Physical Education, Southwest University, No.2 Tiansheng Road, Beibei District, Chongqing, China.
康杰克葡萄甘 (KGM) 补充剂改善了便秘症状,并改变了精英运动员的肠道微生物群. 这种饮食干预措施为体验功能性便秘的运动员提供了潜在的解决方案.
科学领域:
- 胃肠病学 胃肠病学
- 运动营养 运动营养
- 微生物组研究 微生物组研究
背景情况:
- 运动员面临的功能性便秘风险增加,由于强烈的训练和生活方式因素.
- 有限的临床数据存在于治疗运动员的便秘,特别是可溶性纤维,如康雅克葡萄干 (KGM).
研究的目的:
- 为了评估8周的康雅克葡萄甘 (KGM) 干预对胃肠道症状的疗效.
- 为了评估KGM对肠道微生物群组成对功能性便秘的精英男子泰拳道运动员的影响.
主要方法:
- 一个双盲,随机对照试验,涉及精英男性泰拳道运动员,他们被诊断患有功能性便秘 (罗马四号标准).
- 参与者接受了KGM补充剂或安慰剂8周.
- 结果包括患者对便秘症状的评估 (PAC-SYM),生活质量 (PAC-QoL),肠道排便频率 (BMF) 和通过16SrRNA测序进行肠道微生物群分析.
主要成果:
- 与安慰剂相比,KGM组在PAC-SYM,PAC-QoL,BMF和肠功能指数 (BFI) 中显著改善 (p <0.05).
- 微生物分析显示肠道微生物的α多样性增加和特定细菌丰度的变化,包括Prevotella和Lactobacillus的增加.
- 相关性分析将这些微生物变化与症状改善联系起来,功能预测表明代谢途径发生了改变.
结论:
- 康杰克葡萄甘 (KGM) 有效地缓解了患有功能性便秘的精英运动员的胃肠道症状.
- 补充KGM似乎调节肠道微生物群,为改善这种人群中便秘提供了潜在的治疗机制.
更多相关视频
03:50Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
Published on: August 18, 2023
06:01Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
Published on: July 26, 2024
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Drugs Affecting GI Tract Motility: Other Laxatives
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
