酸产品和高尿血的相关性在BMI组中有所不同:一个调解分析研究的研究
Ning Yang1, Jialu Zhuo1, Zhihua Qu1
1Department of clinical nutrition, Shanghai Tenth People's Hospital, Tongji University of Medicine, 301 Yanchang Road, Shanghai, 200072, China.
Clinical rheumatology
|October 21, 2025
概括
酸产物 (Ca×P) 水平升高与美国成年人患高尿血症 (HUA) 的几率更高有关,特别是那些超重或肥胖的人. 血清甘油三显著调解肥胖个体的这种关联.
科学领域:
- 生物化学 生物化学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- -产物 (Ca×P) 和高尿素血 (HUA) 之间的相互作用仍未得到充分研究.
- 了解这种关系对于代谢健康至关重要,特别是在不同的体重指数 (BMI) 群体内.
研究的目的:
- 调查美国成年人中Ca×P水平和HUA患病率之间的关联.
- 为了检查这种关联在不同的BMI类别中是如何变化的.
主要方法:
- 2017-2018年国家健康和营养检查调查 (NHANES) 数据集的横截面分析 (N=5068).
- 利用受限制的立方线,物流回归和调解分析来评估Ca×P-HUA关系.
主要成果:
- 与最低的四分位数相比,Ca×P的最高四分位数与HUA的概率增加了1.31倍.
- 在超重和肥胖个体中观察到Ca×P和HUA之间的正线性关联.
- 在肥胖成年人中,最高的Ca×P四分位数显示HUA的几率增加了1.50倍,血清甘油三调节了这一关联的23.12%.
结论:
- 升高的Ca×P水平与增加的HUA患病率有关,特别是在超重和肥胖人口中.
- 血清甘油三酸在肥胖成年人中的Ca×P-HUA关系中起着重要的调解作用.
- 这些发现突出了潜在的代谢途径,将Ca×P与肥胖个体中的HUA联系起来.
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