使用机械缩模型对人类结肠癌和周围健康组织进行粘弹性建模
Necla Kurt Yusuf1,2, Hooman Salavati1,3,4, Gabrielle H van Ramshorst1,5
1Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Biomechanics and modeling in mechanobiology
|October 21, 2025
概括
瘤组织机制是复杂的. 这项研究开发了先进的机械模型,发现像七元素三重麦克斯韦尔-维赫特 (TMW) 臂模型这样的复杂模型对于80%的瘤组织是必要的,与健康组织不同.
科学领域:
- 生物医学工程 生物医学工程
- 机械生物学 机械生物学
- 在瘤学瘤学.
背景情况:
- 由于样本采集困难,对人类瘤组织的精确机械建模具有挑战性.
- 了解组织机制对于诊断和治疗癌症等疾病至关重要.
研究的目的:
- 开发和比较健康和瘤人体组织的机械模型.
- 为了研究腹膜转移样本中的机械行为的复杂性.
主要方法:
- 在5个腹膜转移样本 (结肠,卵巢,直肠癌) 和2个健康的结肠样本上进行了ex vivo静态痕测试.
- 使用标准线性固体 (SLS) 模型和通用形式,包括双麦克斯韦-维赫特 (DMW) 和三倍麦克斯韦-维赫特 (TMW) 臂模型.
- 采用基于平均平方误差 (MSE) 的交叉验证方法进行模型选择.
主要成果:
- 健康的结肠组织被五要素双马克斯韦-维赫特 (DMW) 臂模型充分描述.
- 80%的瘤组织测量需要更复杂的模型,七元三重麦克斯韦-维赫特 (TMW) 臂模型是最合适的.
- 对于剩余的20%的瘤组织测量,DMW模型足够.
结论:
- 瘤组织比健康的结肠组织具有更大的机械复杂性.
- 先进的机械模型,如TMW模型,是必要的,以准确地表示瘤组织的行为.
- 进一步的本病理学分析可以将生物成分与观察到的机械性质相关联.
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