乳腺癌后体重变化和糖尿病风险:一项全国性的队列研究
Wonyoung Jung1,2, Jinhyung Jung3, In Young Cho4
1Department of Medicine, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Journal of cancer survivorship : research and practice
|October 21, 2025
概括
乳腺癌诊断后保持健康的体重至关重要. 显著的减肥可以降低糖尿病风险,而体重增加会增加糖尿病风险,这凸显了体重管理对乳腺癌幸存者的重要性.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 乳腺癌幸存者 (BCS) 面临糖尿病和体重增加的高风险.
- 诊断后体重变化是BCS健康结果的一个重大问题.
研究的目的:
- 研究乳腺癌诊断后体重变化与随后患糖尿病的风险之间的关联.
- 为BCS提供基于证据的体重管理建议,以减轻糖尿病风险.
主要方法:
- 分析了40850名以前没有糖尿病的BCS队列.
- 体重状况和肥胖 (BMI ≥25 kg/m2) 变化被追踪到诊断前和诊断后.
- 糖尿病发病率是主要结果,并计算了调整后的危险比率 (aHR).
主要成果:
- 在诊断后过渡到肥胖,糖尿病风险增加了45% (aHR 1.45).
- 持续的肥胖与87%更高的糖尿病风险 (aHR1.87) 有关.
- 显著的体重减轻 (>10%) 将糖尿病风险降低了45% (aHR 0.55),而适度的体重增加 (5-10%) 将其增加了18% (aHR 1.18).
结论:
- 诊断后的肥胖与BCS中糖尿病发病率的增加有关.
- 诊断后的大量体重减轻显著降低了糖尿病风险.
- 体重管理是预防乳腺癌幸存者的糖尿病的一个关键策略.
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