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细胞增殖细胞核抗原 (PCNA) 在COVID-19中调节中性粒细胞过活化

Rodrigo de Oliveira Formiga1,2,3, Lucie Pesenti1,2, François Chable de la Héronnière1,2

  • 1Université Paris Cité, CNRS UMR 8104, Inserm U1016, Paris 75014, France.

Proceedings of the National Academy of Sciences of the United States of America
|October 21, 2025
PubMed
概括

中性粒细胞中细胞分裂细胞核抗原 (PCNA) 的升高导致严重的COVID-19炎症. 用T2AA抑制PCNA可减少活性氧物种 (ROS) 和中性粒细胞外细胞陷 (NET) 的形成,提供一种潜在的治疗策略.

关键词:
在 COVID-19 疫情中,这是一个PCNA,PCNA,PCNA.中性粒细胞中性粒细胞.

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