全球心肌工作指数与非缺血性扩张性心肌病的结果之间的关联
Eduard Ródenas-Alesina1,2, Jordi Lozano-Torres1, Clara Badia-Molins1
1Department of Cardiology, Vall d'Hebron University Hospital, Department of Medicine, Universitat Autònoma de Barcelona, Barcelona.
Journal of cardiovascular medicine (Hagerstown, Md.)
|October 21, 2025
概括
全球心肌工作指数 (GMWI) 与非缺血扩张性心肌病 (NIDCM) 的不良结果有关. 然而,它并没有改善NIDCM患者在左心室全球纵向菌株 (LV-GLS) 以外的风险预测.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心血管成像 - 心血管成像
背景情况:
- 左心室全球纵向应变 (LV-GLS) 预测非缺血性扩张性心肌病 (NIDCM) 的不良结果.
- LV-GLS可以受到左心室 (LV) 后负荷的影响.
- 全球心肌工作指数 (GMWI) 包括LV后负载,可能增加风险分层.
研究的目的:
- 评估GMWI是否在NIDCM患者中提供优越的风险分层,而不是LV-GLS.
- 在NIDCM中评估GMWI和不良心血管结果之间的关联.
主要方法:
- 对524名NIDCM患者的回顾性分析.
- 对GMWI和LV-GLS的评估.
- 对于死亡或心力衰竭 (HF) 的结合终点的随访.
主要成果:
- 较低的GMWI与HF病史,较高的E/e'比率和较差的右心室功能相关.
- 观察到GMWI和不良结果之间存在非线性关系,风险停滞在1000mmHg%以下.
- 在调整后,GMWI和LV-GLS的风险预测表现相似,表明GMWI的附加值有限.
结论:
- 在NIDCM中,较低的GMWI与更糟糕的心声学参数和增加HF入院和死亡风险有关.
- 在这个患者队列中,GMWI似乎没有改善超过LV-GLS的风险歧视.
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