跨年龄组的奇孔古尼亚的临床结果:系统性审查
Judith O M Bentvelzen1, Adrianne M de Roo2,3, Gabriel S Gurgel do Amaral1
1Asc Academics B.V., Groningen, the Netherlands.
PLoS neglected tropical diseases
|October 21, 2025
概括
Chikungunya (CHKV) 在不同年龄组呈现不同,老年人和幼儿的住院和死亡率较高. 了解这些CHKV变异对于有效的公共卫生战略至关重要.
科学领域:
- * * 公共卫生 公共卫生
- * 传染病 传染病
- * 流行病学 流行病学
背景情况:
- * Chikungunya病毒 (CHKV) 是蚊子传播的阿尔法病毒,构成了日益严重的全球健康威胁.
- *关于CHKV的特定年龄临床表现的了解有限.
- *识别与年龄相关的差异对于诊断,治疗和预防至关重要.
研究的目的:
- * 系统地评估和比较不同年龄组的奇昆古尼亚的临床表现.
- * 为了确定与年龄相关的CHKV疾病结果的相似性和差异性.
主要方法:
- *对Embase,MEDLINE和灰色文献进行系统文献综述 (搜索日期:2024年9月17日).
- *包括101项报告儿童,成人和老年人的临床结果的研究.
- *使用唐斯和黑色标准进行偏差风险评估.
主要成果:
- *老年人 (≥65岁) 和幼儿 (<18岁) 的住院和死亡率最高.
- *发疹和头痛在成年人 (18-64岁) 和青少年中更常见;发烧在成年人和老年人中更为普遍.
- *关节痛在儿童和老年人中较少发生,可能导致误诊;慢性症状随着年龄的增长而增加.
结论:
- * 奇昆古尼亚呈现的与年龄相关的显著变化需要定制的临床管理和诊断.
- * 调查结果强调需要针对特定年龄的公共卫生政策,以减轻CHKV的全球影响.
- *需要进一步的研究来解决数据异质性问题,特别是对于儿科和老年人群.
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