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对先进的糖化终端产品的新见解诱导了黑色素生和干预策略
Xi Yang1, Mengqi You1, Huanjun Zhou1,2
1The Estée Lauder Companies Innovation, Shanghai, China.
Journal of cosmetic dermatology
|October 21, 2025
概括
先进的糖化终产品 (AGEs) 通过增加黑色素来触发皮肤色素增多. 滴氧 propylresorcinol (DP), niacinamide 和绿茶提取物提供了一种多方面的策略来对抗AGE诱导的皮肤变黑.
科学领域:
- 皮肤病学 皮肤病学
- 生物化学 生物化学
- 化品科学 化品科学
背景情况:
- 皮肤超色素是一种常见的美容问题,由增加的黑色素引起.
- 先进的糖化终产品 (AGEs) 越来越多地被认为是导致超色素的因素.
- 对AGE诱导的黑色素形成的精确机制和有效干预措施需要进一步研究.
研究的目的:
- 阐明AGE诱导黑色素形成的机制.
- 识别和评估潜在的治疗干预措施,以针对AGE诱导的多色素化.
主要方法:
- 皮肤细胞和3D表皮模型被暴露在AGE中,以评估黑色素生产和铁酶活性.
- 评估了Dimethoxytolyl propylresorcinol (DP),尼胺胺和绿茶提取物对AGE诱导的黑色素发生的抑制作用.
- 用质谱和皮肤模型评估DP在破坏AGE交叉链路方面的有效性.
主要成果:
- 在皮肤模型中,AGE暴露显著增加了黑色素的产生和铁酶活性.
- 发现AGEs通过NLRP1/Caspase1激活在纤维细胞中上调IL-33表达.
- DP在打破AGE交叉链路和抑制AGE诱导的黑色素产生方面表现出有效性.
结论:
- 酸,氨胺和绿茶提取物共同针对AGE诱导的黑色素生成的各个阶段.
- 这些化合物提供了一个有前途的治疗策略,用于解决与衰老相关的皮肤多颜色和色.
- 准AGE路径为管理与年龄相关的皮肤问题提供了一种新的方法.
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