riboCIRC v2.0:一个可翻译CircRNAs的扩展资源
Yunhao Xu1, Lei Yang1, Yuewen Tang1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.
Nucleic acids research
|October 21, 2025
概括
更新的riboCIRC v2.0数据库现在列出了超过5000个可翻译的圆形RNA (circRNA) 和它们的. 这个资源加速了研究circRNA翻译和功能表征的研究.
科学领域:
- 基因组学和生物信息学
- 分子生物学分子生物学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 循环RNAs (circRNAs) 越来越多地被认为是它们的调节作用.
- 翻译组包括所有翻译RNA,对于理解细胞功能至关重要.
- 描述可翻译的circRNA及其编码的对于功能基因组学至关重要.
研究的目的:
- 为了介绍 riboCIRC v2.0,一个可翻译circRNA及其编码的显著更新的数据库.
- 加强研究circRNA翻译和功能表征.
- 为各种生物系统提供全面的资源.
主要方法:
- 扩展可翻译circRNAs和有限的ORF编码的数据收集.
- 整合了circRNA翻译的新证据层,包括RNA编辑和RBP相互作用.
- 对编码的特性和功能进行了系统的in silico注释.
主要成果:
- riboCIRC v2.0 文件 5212 个预测可翻译的 circRNA 和 7563 个预测的.
- 增强的证据整合包括核糖体分析,质谱学,IRES,m6A,RNA编辑和RBP相互作用.
- 综合性标注详细介绍了物理化学性质,结构和潜在功能.
结论:
- riboCIRC v2.0提供了大幅扩展的内容和增强的功能.
- 更新的数据库是研究可翻译circRNA及其产物的强大资源.
- 改进的数据探索和可视化有助于对各种生物系统的研究.
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