基于双挤出的3D打印核心外片,用于结直肠输送Mebeverine化
Azin Goudarzi1, Tahmineh Karami2, Hussein Abdelamir Mohammad3
1Department of Biotechnology & Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Drug development and industrial pharmacy
|October 21, 2025
概括
这项研究开发了一种新的3D打印的延迟释放片,用于Mebeverine化,改善了易怒肠综合征 (IBS) 管理. 双挤出3D打印方法成功创建了一个受保护的,可控释放剂型,符合质量标准.
科学领域:
- 制药技术 制药技术 制药技术
- 3D打印应用 3D打印应用
- 药物输送系统 药物输送系统
背景情况:
- 刺激性肠综合征 (IBS) 管理需要有效的药物输送.
- 传统的Mebeverine化配方在受控释放方面可能存在局限性.
- 先进的制造技术为改善药品剂量形式提供了潜力.
研究的目的:
- 使用基于双挤出的3D打印制造一种延迟释放的Mebeverine化片.
- 通过改善药物输送来加强刺激性肠综合征 (IBS) 的管理.
- 为了研究一种新的方法来提供热和酸性药物.
主要方法:
- 使用基于双挤出的3D打印技术.
- 在单个步骤中集成了一个Mebeverine化加载的水凝核心与化挤压的聚合物外.
- 使用压力辅助微注射器 (PAM) 挤出用于水凝核心和化挤出 (ME) 用于外.
主要成果:
- 3D打印的平板显示在酸性条件下药物释放有限,98.6%在酸缓冲区12小时释放.
- 该剂型符合美国药典 (USP) 关于重量变化,易碎性,硬度,测量和内容均性的所有质量规格.
- 扫描电子显微镜 (SEM),里埃转换红外光谱 (FTIR),热重力测量分析 (TGA) 和差分扫描热量测量 (DSC) 证实了结构完整性,化学稳定性和热稳定性.
结论:
- 双挤出3D打印是一种可行的方法,用于制造延迟释放的Mebeverine化片.
- 这项技术为IBS和相关胃肠道疾病的管理提供了一个有希望的策略.
- 这种方法可以为热性和酸性药物提供个性化治疗.
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