RNAPaceDB:一个专门的数据库来剖析不同细胞类型的RNA速度
Hui Liu1, Honghan Zhou1, Siru Yang1
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Nucleic acids research
|October 21, 2025
概括
RNAPaceDB是一种用于RNA速度分析的新数据库,集成数百万个细胞以揭示基因表达动态和细胞转换. 这种资源有助于理解基因调节,发现生物标志物和推进精密医学.
科学领域:
- 系统生物学 系统生物学
- 基因组学就是基因组学.
- 计算生物学 计算生物学
背景情况:
- RNA速度为基因表达动态和细胞状态转换提供了动态见解.
- 了解时间基因调节对于识别生物标志物和治疗点至关重要.
研究的目的:
- 介绍RNAPaceDB,这是一个全面的数据库,用于跨不同细胞类型的RNA速度分析.
- 为探索基因表达动态和细胞发育提供一个平台.
主要方法:
- 整合了144个单细胞RNA测序数据集 (超过210万个细胞,81种细胞类型,41种疾病).
- 使用六种计算模型生成4380个RNA速度流图.
- 开发在线接口用于数据检索和分析.
主要成果:
- RNAPaceDB可用于探索超过18,000个基因的RNA速度配置文件.
- 该数据库有助于分析细胞发育轨迹,差异速度基因和功能丰富.
- 它提供了对细胞分布和监管机制的见解.
结论:
- RNAPaceDB是破译基因表达的时间逻辑的宝贵资源.
- 它支持在系统生物学和精密医学中发现调节机制,生物标志物和治疗点.
更多相关视频
09:15Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
Published on: May 9, 2020
5.6K
12:54Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
Published on: March 7, 2018
14.0K
相关概念视频
03:21RNA-seq
11.7K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.7K
02:24Ribosome Profiling
4.1K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.1K