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在用于甲状腺眼病的teprotumumab治疗后,外眼肌体积的差异变化

Hanna Richkind¹, Marissa K Shoji², Evan Walker¹

¹Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California, San Diego, La Jolla, USA.

Orbit (Amsterdam, Netherlands)

|October 21, 2025

概括

在甲状腺眼病 (TED) 中,teprotumumab显著降低了眼睛肌肉体积和proptosis. 观察到眼外肌肉 (EOM) 体积的减少,但与临床结果的相关性很弱.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
医疗成像医学成像

背景情况:

甲状腺眼睛疾病 (TED) 是一种影响轨道的自身免疫性疾病.
眼外肌肉 (EOM) 和轨道脂肪的变化有助于TED中的proptosis和diplopia.
泰普穆马布是TED的一种新的生物治疗方法.

研究的目的:

为了评估teprotumumab对TED患者个体EOM体积和proptosis的影响.
分析teprotumumab治疗后EOM细分和球体体积的变化.

主要方法:

在teprotumumab治疗前后对轨道成像 (MRI) 和临床数据 (CAS,外视计) 的回顾性审查.
单个EOM (LR,MR,SR,IR) 和全球的手动细分用于体积计算.
处理前后的EOM体积,质和CAS的比较.

主要成果:

采用teprotumumab治疗导致了平均3.69毫米的proptosis减少.
观察到中间直肠 (-20%) 和下直肠 (-28%) 体积的显著减少.
总EOM体积下降了20%,而地球体积保持不变;CAS也有所改善.

结论:

在TED中,teprotumumab有效地降低了EOM体积和proptosis.
虽然发生了EOM体积变化,但它们与临床结果 (CAS,proptosis) 的相关性很弱,这表明其他因素,如轨道脂肪影响反应.

关键词:

眼外肌肉眼外肌肉眼外肌肉这就是为什么teprotumumab.甲状腺眼睛疾病甲状腺眼睛疾病在这个过程中,体积体积体积体积量.

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