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Updated: Jan 14, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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通过限制TNFR1-驱动的STING激活和ZBP1-依赖的细胞死亡,ATG9A介导的自会预防炎症性皮肤疾病

Dario Priem1, Jon Huyghe1, Barbara Gilbert1

  • 1Center for Inflammation Research, VIB, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.

Immunity
|October 21, 2025
PubMed
概括

瘤坏死因子 (TNF) 驱动炎症,但ATG9A缺乏导致通过cGAS/STING依赖的干扰素产生和细胞死亡导致疾病. 自抑制了这种干扰素反应,为炎症性疾病提供了新的治疗点.

关键词:
国际货币基金组织 IFN IFN这就是TNF TNF.灭症 (apoptosis) 是一种死亡的过程.自自是自的过程.细胞死亡是细胞死亡.炎症性疾病是一种炎症性疾病.干扰子干扰子干扰子这是一种干扰性异常疗法.尸体的死亡和死亡.皮肤炎症 皮肤炎症系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.瘤死亡因子是瘤死亡因子.

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