在系统整合期间,前临床皮层子电图的PV依赖性重组
Ali Golbabaei1, Sheena A Josselyn2, Paul W Frankland3
1Program in Neurosciences & Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.
记忆录随着时间的推移而变化. 前极皮层 (PrL) 中不同的神经元子群支持最近与远程记忆的回忆,具体的投影路径对于每个阶段都至关重要.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 记忆研究 记忆研究
背景情况:
- 神经元组合,或内图,是在学习过程中形成的.
- 通过系统整合,Engram组织可以随着时间的推移而改变.
- 了解这些动态变化是记忆研究的关键.
研究的目的:
- 为了研究engram组织在记忆巩固过程中如何发生变化.
- 为了确定涉及近期与远程记忆回忆的特定神经元子群.
- 阐明前极皮层 (PrL) 电路在记忆动态中的作用.
主要方法:
- 在情境恐惧条件化过程中,在PrL皮质中标记engram合奏.
- 评估神经元活动和对近期和远程延迟记忆回忆的贡献.
- 使用化学遗传学来操纵PrL的帕瓦胺表达内部神经元.
主要成果:
- 截然不同的engram子群 (sub-engrams) 有助于最近和远程记忆回忆.
- 最近的召回涉及到向基底杏仁体 (BA) 和侧腔内皮层 (LEC) 投射的PrL子电图.
- 此外,远程回忆还招募了投射到核聚会 (NRe) 和核聚集 (NAc) 的PrL子电图.
- 招募NRe和NAc投射子电图取决于培训后的PrL内部神经元活动.
- 抑制这些内部神经元损害了远程记忆回忆.
结论:
- 恩格拉姆组织是动态的,在系统整合过程中不断发展.
- 神经元亚种群的特定投影形状决定了它们在不同时间点的记忆回忆中的作用.
- PrL 帕瓦胺表达型内部神经元在神经元组合的积极招募中起着关键作用,用于远程记忆检索.
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