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在败血症期间,BRD3的非正规免疫代谢功能

Nian Wang1, Jiao Liu2, Runliu Wu3

  • 1Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pathophysiology, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan 410083, China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, Changsha, Hunan 410083, China.

Developmental cell
|October 21, 2025
PubMed
概括

含有odomain的3 (BRD3) 通过增加免疫细胞中的乙酸脱酶1 (ACOD1) 来驱动败血性休克. 抑制BRD3可以防止败血症,这表明它是一个治疗目标.

关键词:
在 ACOD1 中,ACOD1 是 ACOD1.这就是BRD3D3的意思.免疫代谢的免疫代谢.这是一种炎症炎症炎症炎症.这就是 itaconate.这是一种血症.

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