布普伦诺啡因获取的缺口:检查提供者可用性和治疗连续性的情况
Abolfazl Sadeghi1, J Douglas Thornton2, Tyler J Varisco1
1Pharmacy Addictions Research and Medicine Program, College of Pharmacy, The University of Texas at Austin, United States of America; Health Outcomes Division, College of Pharmacy, The University of Texas at Austin.
Journal of substance use and addiction treatment
|October 21, 2025
概括
对于阿片类药物使用障碍 (OUD) 的布普伦诺芬治疗中,供应商的干扰中断了四分之一的患者的护理. 农村患者面临更高的断药风险,强调需要政策解决方案.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 药物治疗 药物治疗
背景情况:
- 布普伦诺芬是阿片类药物使用障碍 (OUD) 的关键治疗方法.
- 主要提供者对布普伦诺芬处方的中断可能会导致患者护理的重大差距.
- 失去对布普伦诺啡供应商的连续访问,增加了停止治疗的风险.
研究的目的:
- 调查一级布普伦诺啡因供应商停产对治疗连续性的影响.
- 为了确定与在提供者中断后恢复布普伦诺芬药物治疗相关的因素.
主要方法:
- 使用德克萨斯州处方监测计划数据 (2018-2021) 的回顾性队列研究.
- 分析包括单一处方医生的患者,这些患者至少停止处方90天.
- 主要结局是在90天内重新与新提供者建立护理;后勤回归确定了相关因素.
主要成果:
- 24%的患者在他们的主要提供者停止处方后没有重新建立布普伦诺芬护理.
- 农村居住与恢复治疗的几率较低有关 (aOR=0.60).
- 较高的布普伦诺芬剂量 (>8毫克/天) 和较长的先前治疗持续时间 (>60天) 增加了治疗的连续性.
结论:
- 很大一部分患者 (24%) 在停止初级处方后经历了治疗中断.
- 农村患者因这些护理差距而受到不成比例的影响.
- 需要政策干预,包括远程医疗,以确保一致的OUD治疗和减轻干扰.
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