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通过全身输送免疫增强的Staphylococcus epidermidis菌株来加强黑色素瘤治疗

Jeewon Hwang^1,2, Gwanghee Kim^1,2, Yoojin Lee^1,2

¹Department of Microbiology and Immunology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Scientific reports

|October 21, 2025

概括

皮肤细菌Staphylococcus epidermidis AIT01可以增强免疫细胞并对抗黑色素瘤. 它的溶酸盐,特别是与抗PD-1疗法相结合,对癌症免疫疗法有很大的希望.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

葡萄球菌 (Staphylococcus epidermidis) 菌株AIT01具有增强免疫力的特性.
皮肤微生物群是新型免疫疗法的潜在来源.

研究的目的:

评估AIT01菌株的全身免疫调节和抗瘤作用.
研究AIT01溶解酸在黑色素瘤治疗中的治疗潜力.

主要方法:

活体实验评估了胞活力,免疫细胞群 (树突细胞,NK细胞,γδT细胞) 和细胞因子 (IFN-γ) 的产生.
在体内研究中,在患有黑色素瘤的小鼠中,AIT01细菌溶解酸被内和静脉注射.
评估了 lysate 单疗法和与抗PD-1 单克隆抗体联合疗法的抗瘤疗效.

主要成果:

AIT01溶解剂和超剂增加了脊髓细胞的活力ex vivo.
增加了树突细胞,NK细胞和γδ T细胞的数量,观察到IFN-γ和素的产生增强.
显著抑制黑色素瘤生长在体内与AIT01溶解酸,与前治疗是更有效的.
与抗PD-1抗体的联合治疗与单一治疗相比,显示出优异的瘤抑制.

结论:

酸AIT01增强了免疫细胞的增殖和细胞因子的产生,显示出对黑色素瘤有强大的抗瘤作用.
作为一种免疫治疗策略,AIT01的全身输送具有前景.
结合AIT01溶解酸与抗PD-1疗法,为黑色素瘤治疗提供了一种潜在的协同方法.

关键词:

斯塔菲洛科克斯 (Staphylococcus epidermidis) 是一种表皮菌.这是一种抗瘤药物.免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.黑色素瘤是一种黑色素瘤.皮肤的微生物群.

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