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Updated: Jan 14, 2026

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帕洛西丁通过调节AKT/mTORC1通路来抑制THP-1人类单细胞中27-基胆固醇诱导的反应

Dongha Park1, Yonghae Son1, Dongjun Lee2,3

  • 1Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea.

Scientific reports
|October 21, 2025
PubMed
概括

帕洛西丁 (PRX) 抑制了由免疫氧醇触发的单细胞细胞中的炎症反应. 这种抗抑郁药物抑制关键信号通路,减少炎症并恢复免疫细胞功能.

关键词:
这是一种27-基胆固醇.代谢性炎症是一种代谢性炎症.单细胞 (Monocytes) 是一种单细胞.帕洛克西丁 (paroxetine) 是一种药物.

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