在具有复杂基因组特征的软组织肉瘤中使用联合深度学习进行转移性复发的多模式预测
Charles Maussion1, Jean-Michel Coindre2, Jean-Yves Blay3
1Owkin, Paris, France. charles.maussion@gmail.com.
Scientific reports
|October 21, 2025
概括
使用组织学和临床数据的深度学习工具SarcNet准确地预测软组织瘤 (STS) 的转移性复发. 这种AI模型有助于临床医生识别高风险患者,以便及时做出治疗决策.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 软组织肉瘤 (STS) 是复杂的癌症,预测转移对于治疗计划至关重要,特别是辅助化疗.
- 目前的预测方法需要改进,以准确识别患有转移性复发高风险的患者.
研究的目的:
- 开发和验证SarcNet,一种多式深度学习算法,用于预测肢体和干壁STS患者的转移性复发.
- 为了比较SarcNet的性能与现有的预测工具,如Sarculator nomogram和FNCLCC等级.
主要方法:
- SarcNet是使用组织学整体幻灯片和临床变量开发的.
- 在两个独立的多中心数据集 (Léon Bérard中心和Bergonié研究所) 中使用联合学习进行了隐私增强培训.
- 该算法在来自同一机构的两个额外的独立队列中得到验证.
主要成果:
- 在交叉验证中,SarcNet实现了0.797的接收器运行特征曲线 (AUC) 下的面积,用于预测5年转移性自由存活率 (MFS).
- 性能与最先进的Sarculator nomogram (0.778 AUC) 相似,并且显著超过了FNCLCC分级 (0.706 AUC).
- 解释性分析揭示了组织学模式,如非典型性,瘤细胞性和异糖症作为关键预测因素.
结论:
- SarcNet在预测STS转移性复发方面表现出很高的表现,与现有方法相比,性能优于当前的分级系统.
- 该模型识别高风险患者的能力可以帮助临床医生优化治疗策略,包括新辅助或辅助疗法.
- 通过SarcNet的组织学模式识别,可以了解转移性转移性复发的生物驱动因素.
更多相关视频
09:53Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
Published on: August 16, 2020
7.6K
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
485
相关概念视频
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
