严重精神疾病患者非自然死亡的危险因素
Faith Dickerson1, Sabahat Khan2, Andrea Origoni2
1Stanley Research Program, Sheppard Pratt, 6501 North Charles St., Baltimore, MD, 21204, USA. fdickerson@sheppardpratt.org.
Scientific reports
|October 21, 2025
概括
患有严重精神疾病的人面临更高的非自然死亡率,通常是由于可预防的自杀和事故. 关键的危险因素包括男性性别,主要抑郁症和细胞大脑病毒抗体.
科学领域:
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 与普通人群相比,患有严重精神疾病 (SMI) 的人的非自然死亡率显著更高.
- 这些可预防的死亡,主要是自杀和意外,突出了严重的公共卫生问题.
- 关于SMI人群中非自然死亡的临床和生物风险因素的前性研究有限.
研究的目的:
- 确定精神分裂症,双相情感障碍或严重抑郁症患者非自然死亡的临床,人口和血清学风险因素.
- 在这个脆弱群体中调查与自杀和意外死亡相关的特定风险因素.
主要方法:
- 对1517名SMI患者进行了前性队列研究.
- 从美国国家死亡指数获得死亡率数据,追踪时间长达23.9年 (18,952人年).
- 最小绝对收缩和选择操作员 (LASSO) 和考克斯比例危险模型用于分析风险因素,并对与自杀有关的死亡进行敏感性分析.
主要成果:
- 共有53名 (3.5%) 参与者死于非自然原因,包括29起自杀/可能自杀和24起意外死亡. 中毒是最常见的原因.
- 在基线确定非自然死亡的独立预测因素是男性性别,主要抑郁症诊断,较低的孕产妇教育,更严重的负面症状,年龄较小,以及对细胞巨乳病毒 (CMV) 的IgG抗体升高.
结论:
- 男性性别,主要抑郁症,较低的社会经济地位指标,症状严重程度,年龄较小和CMV感染与SMI患者的非自然死亡风险增加有关.
- 这些发现强调了针对性干预和在更大的队列中进行进一步研究的必要性,以减轻该人口中可预防的死亡.
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