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从COVID-19中恢复6个月后的精子质量变化:一个回顾性观察性研究

Xiaoli Zhao^1,2, Yu Zhao^2,3, Nan Jiang^1,2

¹Department of Reproductive Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Scientific reports

|October 21, 2025

概括

COVID-19感染暂时影响男性精子质量,降低度和运动能力. 据估计,感染后精子参数的完全恢复需要3-5个月.

科学领域:

生殖医学生殖医学
传染性疾病传染性疾病
安德罗学与人类学

背景情况:

随着COVID-19大流行,人们对SARS-CoV-2对男性生殖健康,特别是精子质量的潜在不良影响表示担忧.
了解COVID-19引起的精子损伤的可逆性和恢复时间表对于评估长期男性生育能力至关重要.
以前的研究表明,SARS-CoV-2对精液参数有负面影响,因此需要对恢复模式进行纵向调查.

研究的目的:

纵向评估在6个月内感染SARS-CoV-2后男性的精子质量参数的变化.
确定COVID-19后的精子度和渐进性运动的恢复时间表.
为了评估感染后的生活质量,心理状态和受影响的男性的性功能.

主要方法:

感染前精子分析数据的男性患者队列在COVID-19后6个月被跟踪.
精子参数 (度,运动性) 在基线和感染后1,2,3,6个月被分析.
综合估计方程 (GEE) 和卡普兰-梅尔生存分析用于统计评估重复测量和恢复趋势.

主要成果:

与感染前水平相比,感染后1个月观察到精子度和逐渐运动率的显著下降.
在2个月和3个月后,观察到精子参数的部分恢复,但在6个月后,水平仍然明显低于基线.
预计精子度的中位恢复时间为5个月,逐渐运动的时间为3个月,不依赖年龄.

结论:

COVID-19感染对男性精子质量产生负面影响,其特点是度和运动率下降.
精子质量显示暂时下降,估计感染后3-5个月的恢复期.
在感染后的第一个月内,没有观察到心理状况,生活质量或性功能的显著异常.

关键词:

在 COVID-19 疫情中,前列腺症状前列腺症状心理状态心理状态是指心理状态.性功能性功能性功能精子质量精子质量

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