在肺瘤中,MAPK14及其相关的lncRNAs被上调
Shahab Shahgaldi1, Bashdar Mahmud Hussen2,3, Solat Eslami4
1Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Scientific reports
|October 21, 2025
概括
这项研究发现,MAPK14和相关的长非编码RNA (lncRNA),特别是ZNRD1ASP和NORAD,在肺瘤中显著上调,这表明它们在肺癌发展中的作用.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 中原激活蛋白激酶14 (MAPK14) 和与之相关的长非编码RNA (lncRNAs) 涉及癌症的发展.
- 了解这些分子在肺癌发病过程中的特定作用对于向治疗至关重要.
研究的目的:
- 为了研究肺瘤中MAPK14和三个lncRNAs (NORAD,HCG11,ZNRD1ASP) 的表达水平.
- 评估它们作为肺癌检测和诊断的生物标志物的潜力.
主要方法:
- 对42对肺瘤和相邻的正常组织样本进行了基因表达分析.
- 使用定量实时PCR测量了MAPK14,NORAD,HCG11和ZNRD1ASP的表达.
- 用接收器操作特征 (ROC) 曲线分析来评估诊断准确性.
主要成果:
- 在肺瘤中,ZNRD1ASP表现出最高的上调 (表达比:10.46),其次是NORAD (9.57),HCG11 (5.11) 和MAPK14 (4.9).
- ROC分析表明,ZNRD1ASP具有最高的精度和曲线下的面积 (AUC).
- 诺拉德显示高灵敏度 (0.78) 和负预测值 (70%),在这些指标中表现优于其他转录.
结论:
- MAPK14及其相关的lncRNAs,特别是ZNRD1ASP和NORAD,在肺癌的发病过程中发挥着重要作用.
- 这些基因显示出作为肺癌诊断生物标志物的潜力.
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