怀孕期间目前如何监测莱维他单疗法? 一个系统的审查
Tessa Rademaker1,2,3, Yeonkyung Goo2,3, May Ching Soh4
1School of Pharmacy, Faculty of science, Utrecht University, Utrecht, The Netherlands.
Clinical pharmacokinetics
|October 21, 2025
概括
在怀孕期间使用 levetiracetam 需要因药理动力学变化而调整剂量. 本综述强调了各种治疗药物监测 (TDM) 策略,强调需要标准化的协议来确保控制和安全.
科学领域:
- 药理学和神经科学 药理学和神经科学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 列维是怀孕期间常用的抗药,具有良好的安全性.
- 怀孕会改变药理动力学,可能会降低 levetiracetam 水平并增加发作频率.
- 治疗药物监测 (TDM) 有助于剂量调整,但缺乏指导方针,导致不一致的做法.
研究的目的:
- 审查目前在怀孕期间使用的 levetiracetam 治疗药物监测 (TDM) 策略.
- 识别TDM方法的变化及其对扣押控制和安全的影响.
主要方法:
- 在主要数据库 (MEDLINE,Embase,PsycINFO,Cochrane) 进行了系统的文献搜索,截至2025年4月.
- 纳入标准侧重于研究报告 levetiracetam 剂量,度,监测,有效性或安全性在孕妇.
- 对所有符合条件的文章进行了偏差风险评估和数据提取.
主要成果:
- 包括的研究表明,在怀孕期间的监测和TDM策略中存在显著的异质性.
- 在某些情况下,发作频率增加.
- 关于 levetiracetam 的孕产妇和胎儿安全性的数据有限.
结论:
- 怀孕期间 levetiracetam TDM 策略的异质性是显而易见的.
- 由于药理动力学变化,需要调整剂量,但没有标准化的TDM协议.
- 未来的研究应该标准化TDM,验证目标度,并评估长期安全结果.
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