抗生素暴露和心血管疾病风险:全国范围的队列研究
Sun Jae Park1, Minseo Kim1,2, Seogsong Jeong3
1Department of Biomedical Sciences, Seoul National University Hospital Seoul National University College of Medicine Seoul South Korea.
Journal of the American Heart Association
|October 21, 2025
概括
长期使用抗生素与心血管疾病 (CVD) 的风险增加有关. 这项研究发现,在韩国成年人中,心血管疾病发病率较高,抗生素暴露时间较长.
科学领域:
- 流行病学 流行病学
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 抗生素的使用可以破坏肠道微生物群,可能影响各种疾病.
- 心血管疾病 (CVD) 风险可能会受到抗生素暴露的影响.
- 需要进一步的流行病学数据来理解抗生素和心血管疾病之间的联系.
研究的目的:
- 调查长期使用抗生素与患心血管疾病的风险之间的关联.
- 在韩国大人口中基于累计抗生素处方日的基础上分析心血管疾病风险.
主要方法:
- 全国范围的回顾性队列研究使用韩国国家医疗保险服务数据.
- 包括2,159,965名年龄在40-79岁的成年人,没有先前的抗生素处方 (2004-2005).
- 追踪参与者至2021年12月31日,将暴露定义为累积抗生素日 (2006-2010) 和结果作为事件CVD (2011-2021).
主要成果:
- 较长的累积抗生素处方日与心血管疾病风险增加相关.
- 对心血管疾病的调整后危险比率随着抗生素暴露时间的延长而增加.
- 与未接触过抗生素的个人相比,暴露在抗生素365天以上的个体对心血管疾病的危险比率为1.10.
结论:
- 长期暴露于抗生素似乎与韩国成年人心血管疾病风险增加有关.
- 这些发现表明存在潜在的联系,需要进一步调查.
- 需要进一步的研究来确认因果关系并探索涉及的生物机制.
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