一种新型的共生菌配方通过恢复肠道微生物群的恒常性来防止氧酸盐结石
Xian-Miao Li1, Yirixiatijiang Amier1, Wen-Long Wan1
1Department of Urology, Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
BMC microbiology
|October 22, 2025
概括
一种新型的共生菌配方通过恢复肠道微生物群平衡和降低酸盐水平,有效地预防酸盐结石. 这种针对微生物组的干预提供了一个有前途的治疗策略,用于高氧化性甲病.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
背景情况:
- 氧化酸 (CaOx) 甲是一种普遍的脏疾病,需要新的预防性治疗方法.
- 肠道微生物群失调与CaOx石质形成密切相关,强调微生物调节作为治疗点.
- 协生菌配方在治疗高氧化尿和预防结石方面表现有前途.
研究的目的:
- 开发和评估一种新型的协生菌配方,用于预防氧沙酸腎病.
- 为了研究共生菌对肠道微生物群组成和功能的作用,在超氧沙流症的老鼠模型中.
- 阐明共生菌调节氧酸盐平衡的机制,并施加抗石效应.
主要方法:
- 通过使用 Lactiplantibacillus plantarum, Lacticaseibacillus casei, Bifidobacterium breve 和银河酸盐 (GOS) 开发了一个共生配方.
- 乙烯糖醇 (EG) 诱导的高氧化性大鼠被用协生菌,益生菌混合物或单独使用GOS治疗了28天.
- 分析了肠道微生物群组成,短链脂肪酸 (SCFA) 生产,肠道屏障完整性和酸盐运输体表达.
主要成果:
- 与单个成分相比,同生菌配方表现出优越的抗石活性,表明了协同作用.
- 同生菌治疗逆转了EG诱导的肠道微生物群丰富性和均性的减少,恢复了微生物群结构.
- 参与SCFA生产的有益品种增加,而由于改善了肠道屏障功能和调节了酸盐输送体表达,系统性酸盐过载量减少.
结论:
- 协生性干预有效地通过调节肠道微生物群失调和氧酸盐平衡来逆转乙烯糖醇诱导的高氧化尿.
- 这项研究提出了一种新型的共生菌配方,作为石病的潜在预防策略.
- 这些发现阐明了协生菌有效性的机制基础,为结石疾病管理提供了治疗进展.
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