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选择性单个毛细细胞转移在新鲜的IVF-ET周期中取得的临床结果比新生IVF-ET周期中的两个分裂胚胎转移更好

Qing Feng¹, Juan Liu¹, Zhiwei Zhou¹

¹Department of Assisted Reproduction, Ganzhou People's Hospital, Ganzhou, China.

BMC pregnancy and childbirth

|October 22, 2025

概括

第4天的选择性单个毛囊移植 (eSMT) 显示出与第3天的双裂解阶段移植 (DCT) 类似的怀孕率. 这种ART策略可以减少双胞胎怀孕和年轻患者的早产风险.

科学领域:

生殖医学生殖医学
在体外受精 (IVF)

背景情况:

辅助生殖技术 (ART) 经常导致多胎妊娠,带来风险.
优化ART以提高怀孕率,同时最大限度地减少多胎仍是一个临床挑战.
有限的数据存在于单个摩鲁拉转移作为常见胚胎转移策略的替代方案.

研究的目的:

为了比较第4天选择性单个毛囊移植 (eSMT) 与第3天双裂解阶段胚胎移植 (DCT) 的临床结果.
评估eSMT在试管婴儿治疗中的有效性和安全性.
确定eSMT是否可以提供与DCT相比较的怀孕率,并降低多胎妊娠的风险.

主要方法:

一个回顾性队列研究利用倾向性得分匹配来比较eSMT和DCT组.
对于每个转移策略,分析了156个匹配的案例.
关键结果包括临床怀孕率 (CPR),活产率 (LBR),双胞胎怀孕率,堕胎率 (AR) 和早产率.

主要成果:

在eSMT和DCT组之间没有发现心肺复苏,AR,LBR或剖腹产率的显著差异.
与DCT组相比,eSMT组显示出明显较低的早产率.
在eSMT组中,单身活产率显著更高.

结论:

在35岁或更年轻的患者中,在第4天选择性单个毛囊移植是第3天双裂解阶段胚胎移植的可行替代方案.
eSMT实现了与DCT可比的临床怀孕率.
这一策略有效地减少了双胞胎怀孕的发生率和相关的早产风险,提供了更安全,个性化的方法.

关键词:

裂变阶段胚胎胚胎的分裂阶段临床怀孕率临床怀孕率胚胎转移是胚胎的转移.莫鲁拉 (Morula) 是一个有机体.倾向性得分匹配的匹配方法

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