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Updated: Jan 14, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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激活NEDD4L通过促进EGFR蛋白质体降解来抑制EGFR驱动的肺腺癌生长

Maojian Chen1,2, Wei Jiang3, Jianhua Zhan1

  • 1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Sun Yat-Sen university, Guangzhou, 510060, China.

Journal of experimental & clinical cancer research : CR
|October 22, 2025
PubMed
概括

准FOXM1/NEDD4L轴促进表皮生长因子受体 (EGFR) 降解,提供针对肺腺癌 (LUAD) 的新策略,并克服 osimertinib 耐药性. 组合疗法对EGFR突变性LUAD显示出希望.

关键词:
欧洲农业基金会 (EGFR) 是一个基金.在FOXM1上.卢阿德 (Luad) 的意思是说.在NEDD4L中,它是NEDD4L.奥西默蒂尼布 (Osimertinib) 是一种药物.在 Verteporfin 中使用.

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