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在辅助生殖技术后怀孕的儿童中,DNA甲基化概况和癌症

Bastien Ducreux^1,2, Julie Firmin^1,3, Lucile Ferreux^1,3

¹Faculty of Medicine, INSERM 1016, Université de Paris Cité, 75014, Paris, France.

Clinical epigenetics

|October 22, 2025

概括

辅助生殖技术 (ART) 可能会改变DNA甲基化,增加怀孕孩子的白血病风险. 许多与ART相关的DNA甲基化变化与白血病有关,这表明存在特定的联系,而不是一般的癌症风险.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生殖医学生殖医学
儿科瘤学儿科瘤学

背景情况:

流行病学研究表明,体外受精 (IVF) 孕育的儿童患白血病风险略有增加.
辅助生殖技术 (ART) 与DNA甲基化修饰有关,可能在子宫内发生.
在儿科癌症中观察到非典型的DNA甲基化模式,这引发了对ART作用的担忧.

研究的目的:

为了研究与ART概念相关的DNA甲基化变化与白血病中发现的变化之间的重叠.
为了确定与ART相关的表观遗传变化是否特别增加白血病风险.

主要方法:

系统的文献查和数据库分析以确定癌症/白血病基因和差异甲基基因 (DMG).
交叉引用基因列表与来自ART表观基因组广泛关联研究 (EWAS) 的DMG数据.
在白血病中分析一致的甲基化模式和已知的基因变异.

主要成果:

超过三分之一的ART相关的DMG也与白血病有关,显示出显著的丰富.
七个基因在ART受孕和白血病/白血病前期之间表现出一致的甲基化变化.
已知有五种ARTDMG是白血病体质/胚胎细胞变化的标,包括ATP10A,CHD2,FBRSL1,FGFR2和SORCS1.

结论:

一小部分与癌症相关的基因显示了由于ART导致的DNA甲基化变化.
白血病中的DNA甲基化乱与与ART概念相关的乱有显著的重叠.
像TP73这样的基因,一种瘤抑制剂,在ART和白血病中显示一致的高甲基化,值得进一步研究与ART相关的白血病风险.

关键词:

辅助生殖技术是一种辅助生殖技术.癌症癌症癌症癌症通过DNA甲基化.在这个过程中,IVF IVF.在白血病中,白血病.

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