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Updated: Jan 14, 2026

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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在CAR-T细胞疗法中预防二次原发性恶性瘤 (SPMs),通过将特定站点的转基因整合到基因组安全港 (GSHs) 中

Pooria Safarzadeh Kozani1,2, Pouya Safarzadeh Kozani3,4

  • 1Research and Development Center of Biotechnology, Tarbiat Modares University, Tehran, Iran. pooriasafarzadeh@modares.ac.ir.

Journal of translational medicine
|October 22, 2025
PubMed
概括

基因组安全港 (GSHs) 提供了一种解决方案,可以预防CAR-T细胞治疗的二次癌症. 位点定向整合到GSH中确保了CAR-T细胞的疗效,没有致癌风险.

关键词:
癌症免疫疗法癌症免疫疗法化学抗原受体的化学抗原受体基因组是安全的港湾.插入性突变发生.二次性原发性恶性瘤.

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Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood09:29

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