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Updated: Jan 14, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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健康衰老中阿尔茨海默病的多基因风险:与年龄相关的和由APOE驱动的对大脑结构和认知的影响

Hao-Jie Chen1,2,3,4, Xinyi Dong1, Yichen Wang1,2,3

  • 1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.

Genome medicine
|October 22, 2025
PubMed
概括

阿尔茨海默病 (AD) 的高多基因风险加快了健康个体的大脑衰老和认知能力下降. 这些影响随着年龄的增长而加剧,特别是通过结构性大脑变化影响记忆和执行功能.

关键词:
在这里,APOEOE是APOE.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.大脑衰老的老化认知能力下降 认知能力下降多基因风险评分多基因风险评分.英国生物银行

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