肠道炎症与轴性脊柱关节炎中的结构性脊柱损伤有关 - - 来自观察性SPARTAKUS队列的结果
Johan Karlsson Wallman1,2, Elisabeth Mogard3,4, Jonas Sagard3,4
1Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden. johan.karlsson_wallman@med.lu.se.
Arthritis research & therapy
|October 22, 2025
概括
通过便calprotectin测量肠道炎症,与轴性脊柱关节炎 (axSpA) 中脊柱损伤的增加有关. 这一发现突显了axSpA的肠-脊柱联系,即使考虑到其他风险因素.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 轴性脊椎关节炎 (axSpA) 经常涉及肠道炎症,影响50-60%的患者.
- 在axSpA的亚临床肠道炎症与疾病活性和脊髓损伤风险相关.
- 便中的calprotectin (F-calprotectin) 作为检测肠道炎症的关键生物标志物.
研究的目的:
- 研究axSpA患者的肠道炎症 (F-calprotectin) 和结构性脊柱损伤之间的关联.
- 为了确定F-calprotectin水平的升高是否会在axSpA.中预测脊髓损伤更大.
- 在非放射性和放射性轴SpA.A.中分析这一关联.
主要方法:
- 76名非放射性和152名放射性 axSpA 患者的横截面研究.
- 使用修改的冲刺结性脊柱炎脊柱评分 (mSASSS) 评估结构性脊柱损伤.
- 通过F-calprotectin水平量化肠道炎症,分类为正常,中度或明显升高.
主要成果:
- 在F-calprotectin水平之间观察到mSASSS的显著差异,较高的水平与更多的脊柱损伤相关.
- 升高的F-calprotectin (≥50 mg/kg) 与总体axSpA组 (aOR 2.2) 和放射性axSpA (aOR 2.9) 中的mSASSS值高于中位数有关.
- 这些关联在调整为已知的脊髓损伤风险因素后仍然显著.
结论:
- 由高F-calprotectin表示的肠道炎症,在axSpA.中与更大的脊柱结构损伤交叉相关.
- 这些发现表明axSpA.肠道炎症和脊柱病理之间存在联系.
- 需要进一步的前性研究来确定肠道炎症是axSpA.脊柱放射性进展的预测因素.
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