在下骨中的巨细胞骨瘤没有典型的组织学特征:一个病例报告
Kaori Oya1, Kouhei Kawamura2, Ryou Akiyama2
1Department of Clinical Laboratory, The University of Osaka Dental Hospital, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. ooya.kaori.dent@osaka-u.ac.jp.
Journal of medical case reports
|October 22, 2025
概括
巨细胞骨瘤 (GCTB) 很少影响下巴. H3.3G34W 当常规组织学不清楚时,免疫染对于诊断下中GCTB至关重要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 口腔和牙面部外科手术
背景情况:
- 巨细胞骨瘤 (GCTB) 是一种局部具有攻击性的瘤,通常在长骨中发现.
- 面GCTB很少见,并且可以呈现异常,使诊断复杂化.
- 这一案例突出显示了下部的GCTB具有不寻常的特征.
研究的目的:
- 在下部呈现一个具有挑战性的GCTB病例.
- 强调非典型的GCTB的诊断困难.
- 突出特定分子标记在诊断中的实用性.
主要方法:
- 一个案例报告,是一名70多岁的日本男子,长达十年的下病变史.
- 诊断成像包括形光束计算机断层扫描.
- 用H3.3G34W免疫染进行了组织病理学检查.
主要成果:
- 图像检测显示左下有一个大,不规则的放射性光病变.
- 最初的活检表明中央巨细胞颗粒瘤.
- H3.3G34W 免疫染证实了GCTB的诊断,尽管没有常规特征.
结论:
- 仅仅通过形态学分析就不足以诊断GCTB.
- H3.3G34W 免疫染色是区分GCTB与其他巨细胞病变的宝贵工具.
- 在大病变中,即使很少发生,也应该考虑GCTB.
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