辅助生殖技术怀孕和自然怀孕的孩子在BRCA1和NBR2附近的甲基化差异
Yunsung Lee1, Håkon Kristian Gjessing1,2, Christian Magnus Page1,3
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Epigenetics
|October 22, 2025
概括
辅助生殖技术 (ART) 可能会在新生儿的BRCA1/NBR2促进体中引起微妙的DNA甲基化变化. 这些表观遗传差异随着时间的推移而减少,并且在长期内不具有统计学意义.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生殖医学 生殖医学
- 发展生物学 发展生物学
背景情况:
- 辅助生殖技术 (ART) 与新生儿的DNA甲基化 (DNAm) 发生变化有关.
- 在接受ART治疗的新生儿中,观察到BRCA1/NBR2促进者的DNAm增加.
- 这些表观遗传变化的持续性在产后仍然不清楚.
研究的目的:
- 为了研究通过ART怀孕的儿童与自然怀孕相比,BRCA1/NBR2促进者的DNA甲基化差异的纵向持久性.
- 为了确定与ART相关的表观遗传特征是否随着时间的推移而稳定.
主要方法:
- 利用挪威母亲,父亲和儿童队列研究 (MoBa) 的纵向DNAm数据.
- 分析了从出生到22岁的105名ART受孕和250名自然受孕儿童的数据.
- 采用线性混合模型,对相关的共变量进行调整.
主要成果:
- 在ART怀孕的儿童在出生时和出生后表现出微妙的BRCA1/NBR2促进体过甲基化.
- 这些DNAm差异随着时间的推移而减少.
- 经过多次测试校正后,观察到的差异在统计学上并没有保持显著.
结论:
- 在BRCA1/NBR2促进体的微妙高甲基化可能是与ART相关的表观遗传特征.
- 这些表观遗传变化的长期持久性和意义需要在更大的队列中进一步调查.
相关概念视频
Genomic Imprinting and Inheritance
36.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.8K
Meiosis I
43.8K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
43.8K
Mismatch Repair
6.3K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.3K
Gene Conversion
10.6K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.6K
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K


