导管切除与心血管重大不良事件和心房动和阻塞性睡眠呼吸暂停患者全因死亡率的减少有关
Ghassan Bidaoui1, Christian Massad1, Joe Abi-Rached1
1Tulane Research Innovation for Arrhythmia Discovery, New Orleans, Louisiana, USA.
Journal of cardiovascular electrophysiology
|October 22, 2025
概括
导管切除可显著降低心血管重大事件和心房 (AF) 和阻塞性睡眠呼吸暂停 (OSA) 的患者的死亡率. 这种AF治疗为管理这两种情况的人提供了生存益处.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种已知的心房动 (AF) 发展和进展的风险因素.
- 在患有并存OSA的患者中,导管切除AF的生存益处尚未得到充分确立.
研究的目的:
- 评估导管切除与主要心血管不良事件 (MACE) 发生率和被诊断患有AF和OSA的患者全因死亡率之间的关联.
主要方法:
- 使用TrinetX电子健康记录 (EHR) 数据库进行的回顾性队列研究.
- 包括18,324名患有AF和OSA的成年患者 (2014年11月至2024年11月),倾向性得分匹配 (1:1) 分为切除 (9162) 和非切除 (9162) 组.
- 随访始于AF诊断后3个月,分析了临床和人口学变量.
主要成果:
- 在807天的中位随访期间,导管切除与MACE (HR:0.596) 和全因死亡率 (HR:0.264) 的显著降低有关.
- 还观察到心力衰竭 (HR:0.376),脑血管疾病 (HR:0.492) 和脑梗塞 (HR:0.390) 的风险降低.
结论:
- 在患有同时存在AF和OSA的患者中,导管切除与MACE和全因死亡率的风险较低有关.
- 该程序还表明,在这个患者群体中,心力衰竭和血栓栓塞事件的风险降低.
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