系统性免疫炎症指数,系统性炎症反应指数和动脉瘤下关节出血的不良结果之间的关联:元分析
Yihong Hao1, Jianfang Zhao1, Jie Han1
1Department of Neurosurgery, The Third People's Hospital of Datong, Datong, Shanxi, China.
Frontiers in neurology
|October 22, 2025
概括
系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 预测了动脉瘤下关节出血 (aSAH) 的不良结果. 此外,SII还可以预测晚期脑缺血,有助于早期风险识别.
科学领域:
- 神经学 神经学
- 炎症标志物是一种炎症标志物.
- 系统性免疫-炎症指数 (SII)
- 系统性炎症反应指数 (SIRI)
背景情况:
- 动脉瘤下关节出血 (aSAH) 是一种关键的神经疾病,与显著的发病率和死亡率有关.
- 确定可靠的生物标志物来预测aSAH患者的不良结果对于及时干预和个性化治疗至关重要.
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 是具有潜在预后价值的新兴炎症标志物.
研究的目的:
- 系统地审查和元分析SII和SIRI之间的关联以及aSAH患者的不良结果.
- 评估SII和SIRI对90天不良结果和延迟脑缺血 (DCI) 等特定并发症的预测价值.
- 为利用SII和SIRI在识别高风险aSAH患者和指导治疗策略方面提供科学证据.
主要方法:
- 一个全面的系统审查和对研究的元分析,发表到2024年8月10日,来自PubMed,Cochrane,Embase和Web of Science.
- 包含的研究的质量评估是使用纽卡斯尔-太华尺度 (NOS) 进行的.
- 两种混合效应模型被用于使用Stata 17.0.0进行诊断价值评估.
主要成果:
- 包括16项涉及4,510名aSAH患者的研究.
- SII显著预测了90天的不良结果 (OR=1.94,AUC=0.77) 和DCI (OR=1.39,AUC=0.80).
- SIRI预测了不利的90天结果 (OR=1.19,AUC=0.79),但不是DCI或术后肺炎的显著预测因素.
结论:
- 在aSAH中,SII和SIRI都是90天不良结果的有价值的预测生物标志物.
- SII证明了DCI的额外预测价值,提高了其临床实用性.
- 需要进一步的研究来验证SII和SIRI在aSAH管理中的临床适用性.
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