相关实验视频

Updated: Jan 14, 2026

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

心脏移植患者的血栓式微血管病 (TMA):一个复杂的临床病理困境

Mark A Colantonio¹, Bailey Hixon¹, Kevin Felpel²

¹Department of Medicine, West Virginia University, Morgantown, West Virginia, USA.

Case reports in medicine

|October 22, 2025

概括

长期使用塔克罗利斯可以导致药物诱导的血栓性微血管病变 (TMA),这是一种罕见的血液溶解性贫血形式. 对于移植患者来说,对TMA的警至关重要,因为早期检测和干预是关键.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
血液学血液学血液学
移植移植移植移植

背景情况:

药物诱导的血栓性微血管病变 (TMA) 是一种罕见但严重的并发症.
微血管病性血液溶解性贫血 (MAHA) 可能由TMA引起.
塔克罗利马斯是器官移植中的重要免疫抑制剂.

研究的目的:

报告疑似与长期塔克罗利斯治疗相关的药物诱导的TMA病例.
强调对塔克罗利斯诱导的TMA临床怀疑的重要性.
为了为关于这个协会的有限文献做出贡献.

主要方法:

案例报告的呈现方式.
对临床表现和患者病史的审查.
对TMA的差异诊断的讨论.

主要成果:

一名患者在慢性塔克罗利斯 (tacrolimus) 给药后出现了疑似药物诱导的TMA.
这一案例强调了排除其他TMA原因的诊断挑战.
这突显了长期使用氨酸抑制剂和TMA之间的潜在关联.

结论:

临床医生应在长期服用塔克罗利斯的患者中保持对TMA的高度怀疑指数.
需要进一步的研究来阐明慢性塔克罗利木斯使用与TMA之间的关联.
迅速识别和管理塔克罗利斯诱导的TMA对于患者的治疗结果至关重要.

关键词:

微血管病的血液溶解性贫血症细分性硬化症细分性硬化症这就是塔克罗利斯.血栓性微血管病变 - - 血栓性微血管病变

更多相关视频

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

相关概念视频

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...