Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

533
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
533
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

473
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
473
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

822
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
822
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

924
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
924

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cardiac Postpneumonectomy Syndrome: Prevention Is Not Possible.

Annals of thoracic surgery short reports·2026
Same author

Machine learning-driven clinical decision support for liver cirrhosis: a gut microbiome-based web prediction model with explainable AI integration.

BMC gastroenterology·2026
Same author

Tetanus, diphtheria and pertussis vaccination and risk for incident dementia among adults with down syndrome.

The journal of prevention of Alzheimer's disease·2026
Same author

The Society of Thoracic Surgeons 2026 Expert Consensus on the Multimodal Treatment of Pleural Mesothelioma.

The Annals of thoracic surgery·2026
Same author

The safety, reactogenicity, and immunogenicity of the self-amplifying mRNA COVID-19 vaccine GRT-R910 as a booster in healthy adults.

Vaccine·2026
Same author

Controlled human infection with Mycobacterium tuberculosis: practical considerations for clinical trials.

The Lancet. Microbe·2026

相关实验视频

Updated: Jan 14, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.5K

Th9细胞提供保护性结核病免疫力.

Mei Xia1, Azra Blazevic1, Huan Ning1

  • 1Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, MO, United States.

Frontiers in immunology
|October 22, 2025
PubMed
概括

以前与过敏相关的CD4+Th9细胞,通过抑制Mycobacterium tuberculosis (Mtb) 的生长,令人惊地防止结核病 (TB). 这一发现表明Th9细胞可能是未来结核病疫苗开发的新目标.

关键词:
在BCG中,BCG是BCG.它们有IL-9和IL-9.在Th9细胞中.支气管气泡洗是一种支气管气泡洗.结核病菌菌菌的结核病菌的结核病.转录基因检测试验

更多相关视频

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

11.0K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.4K

相关实验视频

Last Updated: Jan 14, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.5K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

11.0K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.4K

科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 传染性疾病 传染性疾病

背景情况:

  • 已知CD4+Th9细胞是炎症和过敏性疾病中的参与者.
  • 对于IL-9/Th9在调节免疫反应,特别是对抗Mycobacterium tuberculosis (Mtb) 的作用,仍然基本上是未知的.
  • Th9细胞与潜伏结核病感染和BCG疫苗接种中的T细胞反应有关.

研究的目的:

  • 研究Th9细胞对Mtb感染的保护作用.
  • 探索Th9细胞作为新型结核病疫苗战略的目标的潜力.

主要方法:

  • 生成和表征了小鼠和人类的Th9细胞.
  • 在体外评估了Th9细胞对细胞内Mtb生长的抑制.
  • 利用IL-9中和IL-9治疗来评估IL-9的作用.
  • 通过收养将Th9和Th1细胞转移到Mtb感染的小鼠中.
  • 分析了宿主免疫反应和感染后的细菌负载.

主要成果:

  • 鼠和人类的Th9细胞都显著抑制了细胞内Mtb生长.
  • IL-9 中和降低了Th9细胞的保护作用,而单独IL-9治疗就抑制了Mtb.
  • 收养Th9细胞的转移赋予了与Th1细胞相比较的强大保护,防止Mtb感染.
  • Th9细胞表现出独特的体内持久性和独特的分子标记 (IL-9,IL-10,PU.1) 没有IFN-γ反应.

结论:

  • Th9细胞通过一种可能独立于Th1介导免疫的机制,对Mtb感染提供显著的保护.
  • Th9细胞是开发创新的结核病疫苗策略的有希望的目标.