在类风湿性疾病中补充,铜和:叙述性审查
Jozélio Freire de Carvalho1, Ana Tereza Amoedo Martinez2,3
1Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEC), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
Mediterranean journal of rheumatology
|October 22, 2025
概括
补充剂对类风湿性关节炎和贝希特病有希望,改善症状和炎症标志物. 铜补充剂在风湿性疾病中没有显著的治疗益处.
科学领域:
- 类风湿病学 类风湿病学
- 营养免疫学 营养免疫学
- 微量元素的新陈代谢
背景情况:
- 像 (Zn),铜 (Cu) 和 (Mn) 这样的微量元素对于免疫功能和氧化应激调节至关重要.
- 这些元素的水平变化与类风湿性关节炎 (RA) 和全身性红斑狼 (SLE) 等类风湿性疾病有关.
- 对于Zn,Cu和Mn补充剂在风湿病中的治疗潜力,需要进一步研究.
研究的目的:
- 审查有关,铜和补充剂在被诊断为类风湿性疾病的患者中有效性的现有证据.
- 综合了随机对照试验和观察性研究关于瘤学中微量元素补充剂的发现.
主要方法:
- 在PubMed,Scielo和LILACS数据库中进行了系统的文献搜索,涵盖了1965年至2024年4月的研究.
- 该审查遵循PRISMA指导方针,包括随机对照试验和关于Zn,Cu或Mn补充剂在风湿性疾病中的观察性研究.
- 四项研究符合纳入标准,专注于Zn和Cu补充剂.
主要成果:
- 补充剂在RA和贝希特病中显示出临床和免疫学的益处,减少疾病活性和改善炎症标志物.
- 铜补充剂在RA和SLE患者中没有显著的治疗效果.
- 在接受补充剂的参与者中,有4%至33%的人报告了轻微的胃肠道副作用.
结论:
- 补充似乎对特定的类风湿性疾病有益,如RA和贝希特病.
- 铜补充剂目前在研究的类风湿性疾病中没有显著的治疗价值.
- 需要进一步进行高质量的随机对照试验,以确定在风湿性疾病中补充微量元素的最终临床建议.
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