使用圣乔治呼吸道问卷活动领域验证修改后的BODE指数
Jong Hun Park1,2, Ha Jin Lee1,2, Chin Kook Rhee3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
ERJ open research
|October 22, 2025
概括
修改后的BODE (mBODE) 指数,使用SGRQ活动域,比传统的BODE指数更好地预测COPD患者的恶化. 这两种指数都有效预测死亡率,mBODE的表现相似.
科学领域:
- 肺部医学 肺部医学
- 临床流行病学临床流行病学
- 呼吸系统疾病研究 呼吸系统疾病研究
背景情况:
- 身体质量指数,阻塞,呼吸障碍和运动指数 (BODE) 是COPD预后的一个有价值的工具,但在临床实践中可能很困难.
- 开发了一个修改后的BODE (mBODE) 索引,用圣乔治呼吸道问卷 (SGRQ) 活动域取代运动组件.
研究的目的:
- 评估mBODE指数与COPD患者基线临床特征的关系.
- 将mBODE指数的预测性能与传统的BODE指数进行比较,用于恶化和全因死亡率.
主要方法:
- 分析了来自韩国COPD小组研究队列中的1765名个体的数据.
- 通过将SGRQ活动域划分为四分位数来定义mBODE指数,取代BODE指数的运动组件.
- 分析了两种评分与1年恶化和全因死亡率之间的关联.
主要成果:
- BODE和mBODE指数都与中度至重度和重度恶化有关.
- 与基于AIC和日志概率值的BODE指数相比,mBODE指数显示了未来恶化频率和存在的优异预测性能.
- 这两种指数都预测了COPD患者的全因死亡率,mBODE显示出显著的关联 (aHR=2.00,p<0.01).
结论:
- mBODE指数有效地反映了COPD的临床特征.
- mBODE指数对恶化和死亡率的预测性能与传统的BODE指数相当.
- 在常规的临床环境中,mBODE指数为评估COPD预后提供了一个潜在的更实用的替代方案.
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