在结直肠癌手术后出现解剖性泄漏的患者中,肠道微生物群的差异
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Updated: Jan 14, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
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Junfeng Yan1, Qiushuang Wang1, Qiang Li1
1Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in microbiology
|October 22, 2025
概括
肠道泄漏 (AL) 的风险与肠道细菌有关. 较高水平的Lachnospiraceae,Bacteroidaceae和Fusobacteriaceae会增加AL的风险,而Lactobacillus可能会对这种结直肠手术并发症提供保护.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 手术瘤学手术瘤学
背景情况:
- 截面泄漏 (AL) 仍然是结直肠手术的严重并发症,患病率持久,机制不明.
- 新出现的证据突出显示肠道微生物群与AL发生之间存在显著的关联.
研究的目的:
- 在结直肠手术后发展AL的患者中调查手术前的肠道微生物群.
- 使用16S rRNA测序来识别影响AL风险的细菌物种.
- 在动物模型中评估Lactobacillus对AL的保护作用.
主要方法:
- 从患有AL和没有AL的结直肠手术患者收集手术前便样本.
- 16S rRNA测序以分析肠道微生物群的组成.
- 在手术前,向小鼠口服Lactobacillus casei Zhang.
主要成果:
- 患有AL的患者表现出肠道微生物群多样性的增加.
- 在AL患者中观察到拉克诺斯皮拉属,杆菌属和杆菌属的种群明显增加.
- 在AL患者中发现了较低的Lactobacillaceae水平,而Lactobacillus补充剂减少了小鼠的AL发病率 (P <0.05).
结论:
- 特定的肠道细菌 (Lachnospiraceae,Bacteroidaceae,Fusobacteriaceae) 可能会导致AL的发展.
- 乳酸菌似乎具有保护作用,可能防止AL.
- 在手术前补充Lactobacillus可能会提供一种新的策略来预防道泄漏.
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