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血清25-基维生素D度与血小板与高密度脂蛋白胆固醇的比率之间的关联:来自两个基于人群的研究的证据

Ming Wang^1,2, Zhi-Long Huang^1,2, Cong-Liang Rao^1,2

¹The Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, Anhui, China.

Frontiers in nutrition

|October 22, 2025

概括

较高的维生素D水平与较低的血小板与HDL胆固醇比率 (PHR) 相关,这是代谢健康的标志物. 这种反向关联在女性中尤为明显,表明维生素D.

科学领域:

生物化学和新陈代谢
营养科学营养科学
流行病学流行病学

背景情况:

血小板与高密度脂蛋白胆固醇 (PHR) 的比率是炎症和代谢健康的新兴生物标志物.
维生素D在生理过程中起着至关重要的作用,包括免疫功能和脂质代谢.
了解维生素D和PHR之间的关系可能会为代谢健康提供见解.

研究的目的:

调查血清25-氧维生素D [25(OH) D]度与血小板与高密度脂蛋白胆固醇比率 (PHR) 之间的关联.
分析这种关系在不同的人群中,特别是美国 (NHANES) 和中国.
探索维生素D与PHR关系中的潜在性别差异.

主要方法:

对两个大型基于人口的数据集进行横截面分析:NHANES (n=36,238) 和一个中国队列 (n=1,122).
测量血清25(OH) D,并计算PHR (血小板计数/HDL-C).
使用权重线性回归和限制立方线 (RCS) 来评估关联,调整混因子. 进行了分层分析.

主要成果:

在NHANES队列中,血清25(OH) D水平和PHR之间发现了显著的反向关联,较高的维生素D与较低的PHR相关.
这种反向关系在中国队列中得到证实,并且在调整多个混因素后仍然存在.
这种关联在两个人群中的女性中更强,表明了显著的相互作用效应.

结论:

血清25(OH) D水平与PHR显著负相关,特别是在女性中.
这些发现表明,维生素D可能在调节PHR方面发挥作用,可能会影响代谢健康.
需要进一步的研究来确定因果关系并阐明潜在的生物机制.

关键词:

25氧维生素D是一种25-氧维生素.人权保护委员会 (PHR)综合数据集的数据集组合.血小板与高密度脂蛋白胆固醇的比例.维生素D是维生素D的重要组成部分.

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