饮食碳水化合物摄入量与多发性硬化症风险之间的关联:一项大型队列研究
Qi Yuan1, Manli Wang1, Shuhui Chen1
1Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
Frontiers in nutrition
|October 22, 2025
概括
高碳水化合物摄入量,包括糖和纤维,与患多发性硬化症 (MS) 的风险增加有关. 这项研究表明,一种潜在的饮食因素会影响多发性硬化症的发展,因此需要进一步研究潜在的机制.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 饮食,特别是碳水化合物摄入量在MS风险中的作用尚不清楚.
- 了解饮食影响对于潜在的MS预防策略至关重要.
研究的目的:
- 研究饮食碳水化合物摄入量与患多发性硬化症 (MS) 的风险之间的关联.
- 分析各种类型的碳水化合物 (总碳水化合物,糖,纤维,果糖,葡萄糖) 与MS发病率之间的关系.
- 探索潜在的剂量反应关系和碳水化合物-MS风险关联中的子组变化.
主要方法:
- 一项前性队列研究涉及210,483名来自英国生物银行的参与者.
- 通过使用重复的24小时饮食回忆来评估饮食碳水化合物摄入量.
- 多发性硬化症 (MS) 病例使用国际疾病分类第10版 (ICD-10) 医院记录中的 G35 代码进行鉴定.
- 考克斯的比例危险模型被用来分析碳水化合物摄入量与MS风险之间的关联.
主要成果:
- 在长达13.25年的随访期间,发现了495例发生性多发性硬化病例.
- 增加总碳水化合物,总糖,纤维,果糖和葡萄糖的摄入量与更高的MS风险有关 (HRs在1.20至1.25的IQR增加).
- 在这些碳水化合物类型和多发性硬化风险之间观察到线性剂量反应关系,在年龄和性别子组中观察到差异.
结论:
- 更高的碳水化合物消费,包括糖和纤维,与多发性硬化症 (MS) 的风险增加有关.
- 这些发现突显出一种潜在的饮食与MS风险的联系.
- 需要进一步的研究来了解连接碳水化合物摄入量和MS病变的生物学机制.
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