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写给编辑的信:回复托普坎等人

Shengjin Dou^1,2,3,4,5, Guopei Zhu^1,2,3,4,5

¹Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Clinical and translational radiation oncology

|October 22, 2025

概括

对高风险的头腺状囊性癌 (ACC) 进行术后并发化疗 (CCRT) 并不建议进行例行治疗. 需要进行进一步的前性试验,以确认ACC患者的生存益处和管理治疗毒性.

科学领域:

在瘤学瘤学.
头部和部手术头部和部手术

背景情况:

高风险的头腺状囊性癌 (ACC) 提出了独特的治疗挑战.
术后并发化疗放射治疗 (CCRT) 在管理ACC中的作用仍在调查中.
对ACC患者来说,平衡潜在的生存益处与与治疗相关的毒性至关重要.

研究的目的:

为解决有关手术后并发化疗放射治疗 (CCRT) 在高风险的头腺囊性癌 (ACC) 的考虑.
讨论关于ACC治疗中CCRT的现有证据和局限性.
突出需要前性试验,以建立最终的治疗指南.

主要方法:

作者承认并回复了一封在ACC中讨论CCRT的信.
该回应审查了关于CCRT有效性和ACC中毒性的现有观点.
讨论了以前研究的局限性,包括小样本大小.

主要成果:

在没有前性证据的情况下,不能为头腺囊性癌 (ACC) 标准推并发化疗 (CCRT).
虽然化疗在局部控制和生存方面可能有好处,但它增加了毒性风险.
在以前的研究中,样本规模很小,这限制了检测显著差异的能力,强调了需要更大规模的多机构合作的需要.

结论:

在前途试验证明足够的生存益处之前,不建议在ACC患者中常规使用CCRT.
解决低发病率和患者招募速度缓慢的挑战对于未来的ACC研究至关重要.
跨机构合作是开展可靠研究和改善ACC治疗结果的关键.

关键词:

同时进行化疗或放射治疗.强度调节的放射治疗强度调节的放射治疗.辐射毒性辐射毒性

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