氧马可以通过重塑肝脏免疫微环境和肠道菌群恒温来缓解 Echinococcus multilocularis 感染
Yazhou Zhu1, Peijiao Wu1, Rou Wen1
1School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Frontiers in cellular and infection microbiology
|October 22, 2025
概括
氧氨酸 (OMT) 在体外直接抑制 Echinococcus multilocularis 的生长,并在体内通过调节肠道微生物群和增强 CD8+ T 细胞来产生抗感染作用,从而为膜球性球菌提供了潜在的治疗方法.
科学领域:
- 寄生虫学的寄生虫学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 气泡状赤球菌 (AE) 是一种严重的动物性传染病.
- 肠道微生物群的调节失调与AE病变产生有关.
- 来自Sophora flavescens的oxymatrine (OMT) 调节肠道微生物群,并在其他疾病中表现出治疗潜力.
研究的目的:
- 在体外和体内研究OMT对 Echinococcus multilocularis (E. multilocularis) 的影响.
- 在AE小鼠模型中探索OMT对肠道微生物群和宿主免疫反应的影响.
主要方法:
- 在实验室中对E. multilocularis protoscoleces进行了活力测试,该实验室使用了不同度的OMT.
- 在体内AE小鼠模型接受OMT (25-100 mg/kg) 或阿尔本达治疗.
- 用于肠道微生物群分析的16S rRNA测序.
- 组织病理学检查和流细胞测量用于免疫细胞分析 (CD4+,CD8+T细胞,B细胞).
主要成果:
- 在体外,OMT显著降低了E. multilocularis protoscolex的活力.
- 在体内,OMT治疗降低了囊重量,缓解了肝炎和纤维化,并增加了CD8+ T细胞.
- OMT干预增强了肠道微生物群的多样性.
结论:
- OMT对E.multilocularis.表现出直接的抗寄生虫活性.
- OMT通过调节肠道微生物群和增强体内CD8+T细胞反应来证明AE的治疗潜力.
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