案例报告: 化学疗法诱导的狗炎:诊断方法和管理策略
Seoyoung Hwang1, Heejeong Hong1, Joohyun Jung1
1Ilsan Animal Medical Center, Goyang, Republic of Korea.
Frontiers in veterinary science
|October 22, 2025
概括
本案例报告详细介绍了第一例记录的化学疗法诱导的狗炎病例,这是一种与多克索鲁比辛和碳白金相关的并发症. 及时诊断和抗炎药物和低水平激光疗法 (LLLT) 的结合导致了成功的管理.
科学领域:
- 兽医瘤学 兽医瘤学
- 药理学 药理学是指药理学的学科.
- 诊断成像 诊断成像 诊断成像
背景情况:
- 骨髓瘤是狗群中常见的一种骨癌,通常用肢体截肢和化疗来治疗.
- 化疗诱导的,人类瘤学中已知的并发症,在兽医中报告不足.
- doxorubicin 和 carboplatin 是经常使用的化疗剂,具有潜在的血管副作用.
研究的目的:
- 报告第一例兽医病例的化学疗法诱导的狗炎.
- 描述这种并发症的诊断方法和治疗策略.
- 为了强调识别和管理接受化疗的狗炎的重要性.
主要方法:
- 一只患有骨肉瘤的7岁黄金回归犬接受了辅助化疗,交替使用碳白金-多克索鲁比辛.
- 炎是通过超声波诊断的,揭示了脑静脉壁的加厚,血栓和.
- 治疗包括皮质类固醇,口服药物 (clopidogrel,pentoxifylline,doxycycline,维生素E) 和低水平激光疗法 (LLLT).
主要成果:
- 狗在多克索鲁比给药后发展出局部,通过超声波检查得到证实.
- 与口服药物和LLLT的联合治疗实现了临床改善.
- 尽管最初取得了成功,但炎在其他静脉中复发,但使用相同的治疗方法进行了管理.
- 患者完成了化疗,骨髓瘤没有复发,并且在13个多月内保持稳定.
结论:
- 化疗诱导的炎是 doxorubicin 和 carboplatin 在狗的潜在并发症.
- 超声波对于诊断和监测炎至关重要.
- 预防性皮质类固醇和辅助的LLLT可以提供有效的预防和治疗策略.
- 早期识别和个性化管理是兽医瘤学中化疗相关的炎的关键.
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