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恶性黑色素瘤与垂体转移:一个病例报告和文献综述

Xiaoling Li¹, Wenhui Jiang¹, Xiaohui Tang¹

¹Department of Pathology, The Second Hospital of Longyan, Longyan, China.

Frontiers in endocrinology

|October 22, 2025

概括

恶性黑色素瘤的垂体转移是罕见的. 综合临床,成像,病理和分子数据的多式诊断对于准确的管理和改善结果至关重要.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
病理学病理学病理学

背景情况:

恶性黑色素瘤 (MM) 的垂体转移是一种不常见的临床表现.
准确的诊断是具有挑战性的,因为缺陷性MM的罕见性和多样化的呈现.

研究的目的:

为了探索恶性黑色素瘤下垂体转移的诊断特征.
通过多式模式的方法来总结这种罕见疾病的病变和诊断挑战.

主要方法:

追溯分析报告的24例垂体转移性MM病例,包括一个新病例.
包括详细的临床,成像,病理和分子数据.
索引患者接受了组织病理学,免疫组织化学 (S100,SOX10,Melan-A,HMB-45,BRAF V600E) 和BRAF V600E PCR.

主要成果:

该研究分析了24例病例,显示男性占主导地位,中位数发病年龄为62岁,频繁发生BRAF V600E突变.
指数患者呈现了上皮状和状细胞特征,对S-100,维门丁,BRAF V600E和焦点Melan-A/HMB-45.5呈阳性.
平均存活时间为12个月,在指数病例中确认了BRAF V600E突变.

结论:

诊断垂体MM转移需要整合临床病史,成像,病理学和分子检测.
一个全面的,多学科的方法对于管理非典型的垂体质量和改善患者的结果至关重要.

关键词:

在BRAF V600E中使用.案例报告案例报告恶性黑色素瘤是一种恶性黑色素瘤.多模式诊断多模式诊断下垂体转移的转移

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